Postdoctoral Fellow – Cardiac Drug Discovery

Lexeo Therapeutics is seeking a Postdoctoral Fellow to join our Discovery & Translation team in San Diego, CA. The individual in this role will play a critical role in the discovery and development of novel therapeutics by supporting therapeutic design, in vitro screening, and sample analysis. The ideal candidate will have a strong background in cellular and molecular biology with some experience in analyzing complex datasets. This is a hands-on laboratory role with the opportunity to guide research strategy.  

• Lead and drive drug discovery efforts through the use of computational and informatics approaches 
• Support the design and execution of in vitro screening studies to advance drug discovery efforts   
• Coordinate and analyze RNA-seq datasets in support of drug discovery 
• Employ a variety of cellular and molecular assays, (e.g. imaging, qPCR/ddPCR, western blot, MSD) to support drug discovery efforts 
• Analyze and interpret data from in vitro studies to provide recommendations to internal stakeholders 
• Collaborate within and across teams to advance drug discovery and development projects 
• Maintain current, detailed documentation of experimental designs, results, and analyses using an electronic laboratory notebook  

• Ph.D. in Biology, Biomedical Sciences, Bioinformatics, Computational Biology, or related field with 0-3 years of post-graduate research experience 
• Knowledge and experience using bioinformatics workflows 
• Experience with RNA-seq analysis, including QC, normalization, and differential expression analysis 
• Hands-on experience with a variety of cellular systems; experience with cardiomyocytes is a plus 
• Deep knowledge of cellular and molecular biology techniques (e.g.flow cytometry, imaging, RNA/DNA isolation, ddPCR, western blot) 
• Must be able to effectively document research efforts in an electronic laboratory notebook  
• Excellent communication, presentation, and project management skills with the ability to effectively convey scientific findings to key internal stakeholders 

LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization.  

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.